Researchers: A/Prof Amanda Leach, Prof Edward (Kim) Mulholland, Dr Heidi Smith-Vaughan, A/Prof Sue Skull, A/Prof Ross Andrews,Prof Jonathon Carapetis, Joseph McDonnell, Dr Vicki Krause, A/Prof Peter Morris (Menzies School of Health Research); Prof Mathu Santoshum (Johns Hopkins Bloomberg School of Population Health, USA); A/Prof Paul Torzillo (RPA Hospita); A/Prof Ngaire Brown (Poche Centre for Indigenous Health); Prof Peter McIntyre (Children’s Hospital Westmead, NSW; Anne Balloch (Murdoch Children’s Research Centre)

Funding: NHMRC

Project summary: A randomised controlled trial of pneumococcal conjugate vaccines Synflorix and Prevenar 13 in sequence or alone in high-risk Indigenous infants (PREV_IX_COMBO): immunogencity, carriage and otitis media outcomes. The combined schedule has the potential to provide protection from multiple bacterial pathogens of high significance. Internationally standardised correlates of vaccine protection, and clinical outcomes, will provide convincing evidence for vaccine policy here and worldwide.

Progress: Ongoing